Hard not to tip Pozzatto for the win, but rarely do guys win 2 years in a row (unless your Merckx). Quickstep seems to have an uphill battle with Bettini and Boonen banged up. Quickstep always seem to get the wins that matter, but given the injuries, I am going to bet against them. Lampre also has to strong chances with Bennati or Ballan.
Rabobank is sending a strong group with Freier, Flecha, Léon van Bon, and Max van Heeswijk. All capable of setting up a sprint or powering a breakaway.
I don't expect a sprint finish as none of the sprinters teams (Milram,Lotto,etc) seem especially strong this season, but you never know. A very long nervous race.
So to cut to the chase my podium predictions are Pozzatto,Bennati, and O'Grady (this is the heart pick not the head -but he has been quietly consistent all season. Filling out the top five will be Schleck and Freire.
If I keep guessing I might eventually call one right...........